It's not the rules that have greatest effect on SCORE. It's the penetration.

You are doing lots of sims for lots of different scenarios. What makes more sense to me is look at the games you have access to, then sim those. If you have local games, that's where you should start. If you are making a trip, look at the games, go back to your hotel room, and run them on your laptop.

What you'll find, as you gain experience, is you can tell how good a game is, and how you should attack it, just by looking at it. Running hundreds of sims with all combinations of rules, game speed (another very important factor), number of players and penetration seems confusing and pointless.